DNA Polymerase β Gap-Filling Translesion DNA Synthesis

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DNA Polymerase β Gap-Filling Translesion DNA Synthesis

Although the primary function of DNA polymerase (pol) β is associated with gap-filling DNA synthesis as part of the DNA base excision repair pathway, translesion synthesis activity has also been described. To further understand the potential role of pol β-catalyzed translesion DNA synthesis (TLS) and the structure-function relationships of specific residues in pol β, wild-type and selected muta...

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DNA polymerase eta is a Y family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous interaction between the PIP box in pol eta and PCNA and between the UBZ in pol eta and monoubiquitin attached to PCNA. Whereas monoubiquitination of PCNA is required for its interaction with pol eta during TLS, we now show that monoubiquitination of pol eta inhibits this ...

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DNA polymerase η is a Y-family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous interaction between the PIP box in polη and PCNA, and between the UBZ in polη and monoubiquitin attached to PCNA. While monoubiquitination of PCNA is required for its interaction with polη during TLS, we now show that monoubiquitination of polη inhibits this interaction, pr...

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ژورنال

عنوان ژورنال: Chemical Research in Toxicology

سال: 2012

ISSN: 0893-228X,1520-5010

DOI: 10.1021/tx300368f